Fluid Bed Top Spray Granulation
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Granulation Granulation is one of the most important unit operations in the production of pharmaceutical oral dosage forms. However, there are many different technologies each having different strengths and weaknesses. Granulation is often required to improve the flow of powder mixtures and mechanical properties of tablets. Granules are usually obtained by adding liquids binder or solvent solutions. Larger quantities of granulating liquid produce a narrower particle size range and coarser and harder granules, i.e. the proportion of fine granulate particles decreases. The optimal quantity of liquid needed to get a given particle size should be known in order to keep a batch-to-batch variations to a minimum. Wet granulation is used to improve flow, compressibility, bio-availability, homogeneity, electrostatic properties, and stability of solid dosage forms. The particle size of granulate is determined by the quantity and feeding rate of granulating liquid. Wet granulation is used to improve flow, compressibility, bio-availability, and homogeneity of low dose blends, electrostatic properties of powders, and stability of dosage forms. Granulator process solutions involve smaller particles adhering to each other in order to grow larger particles or agglomerates. Particle size is critical in a granulator process solution because if the particles are too large or too small they do not have the product characteristics important to produce light powders into high density free-flowing granulates. There are many variables in controlling a granulator process, ranging from feed rate of the granulator liquid to the resonance time of the granulator chamber. All of these parameters affect the particle size in different ways. With an on-line sensor, the particle size is measured instantaneously and continuously in real time helping to monitor and control the granulator process. Granulation methods: Fluid Bed Top Spray Granulation High Shear Granulation Fluid Bed Top Spray Granulation The fluid bed granulation process also known as agglomeration involves suspending particulates in an air stream and spraying a liquid from the top down onto the fluidized bed. Particles in the path of the spray get slightly wetted and become tacky. The tacky particles collide with other particles and adhere to them to form a granule. Granulation can be performed using fluid beds fitted with spray nozzles. It is possible to have completely closed material handling by a closed linking with upstream and downstream equipment. Also, fully automatic cleaning in fluid beds using stainless steel filters now compares favorably with what is possible in a single pot. There are two different modes of fluid bed granulating: • Dry Stage: In Dry stage granulation, the particles only require a slight wetting to become tacky and stick to each other. The granulating solution is applied at a rate less than or equal to the evaporation rate. Thus the particles remain "dry" through the entire process. • Wet Stage: In Wet stage granulation, the particles require significant wetting before they become tacky enough to stick to each other. The granulating solution is applied at a rate higher than the evaporation rate until the particles build up enough moisture to granulate. The characteristics of the particles when wet and the type of granulating solution being used will determine which mode of granulating is most appropriate. While Dry stage is more common, Wet stage granulating allows for denser products.
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npk compound fertilizer granulation plant
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we are pleased to introduce piyali engineering corporation, located in delhi, india. we are leading manufacturer and supplier specializing in the production of sponge plant dri (direct reduced iron) equipment and vital components for steel plants, alongside catering to a diverse range of industries including sugar mills, cement plants, fertilizer plants, chemical plants, coal washeries, activated carbon plants, and ball mills. with a strong focus on quality and innovation, piyali engineering corporation stands as a trusted provider of cutting-edge solutions across various industrial sectors. with a wide range of offerings and a strong customer base, we have been serving the industry for several years. our product range includes various capacities of dri kilns and coolers, ranging from 50tpd to 600tpd & 900tpd, along with components such as support rollers, pinions, shafts, shells, combined bearing housing complete assemblies, spring plates, ball mill pinion shaft, mill head end cover for ball mill manufacturer, girth gears, and more. these offerings are designed to meet the needs of cement plants, power plants, steel plants, sponge iron plants, chemical plants, fertilizer plants, and various other industries. explore top-notch lime kiln paper mill equipment at piyali engineering corporation for customized, cost-effective solutions. our commitment to excellence ensures reliable expertise and high-quality equipment, guaranteeing seamless paper mill operations. specializing in rotary pulp dryers, we provide comprehensive solutions for your paper manufacturing needs. choose piyali engineering corporation, your reliable manufacturer and supplier of fertilizer plant equipment, including rotary calciner kiln spares, mixers, dryers, conveyor systems, rotary drum, rotary cooler spares, and more. our expertise guarantees smooth and efficient fertilizer production operations. our commitment to excellence guarantees seamless operations for industries with reliable equipment and top-notch services. at piyali engineering corporation, we prioritize quality and strive to deliver products that meet and exceed customer expectations. our adept and seasoned team is deeply committed to providing unparalleled service and ensuring utmost customer satisfaction.
granulation plant
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We source only qualitative raw material from the reliable places only. Our professionals conduct strict quality checks as a result of which, finished products stand high on the clients' expectations. Our company stocks the product in mass. Thus, we can cater to bulk/retail requirements with easy and ensure fast delivery of product. Product Details : Eminent design Heavy duty Durable Tested OK Quality assured Smooth functioning
Granules Plant
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Our advanced packaging system assists us in meeting the bulk and customized packaging requirements of the clients. In addition, our packing experts ensure safe packaging of the products. Our prime interest is to deliver a flawless range of products to the buyers. And in this concern, we make all arrangements in order to store the entire lot under safe environment.
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Pharma Integrated Granulation Line
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Wet granulation remains the most widely used process for production of pharmaceutical solid-dosage forms. Modern production processes demand an integrated, scalable, reproducible, and risk-free manufacturing solution. The Gansons Integrated Granulation Suite, called the Force Multiplier® is the preferred wet-granulation solution for the world’s fastest growing regulated pharmaceutical companies. The Gansons Force Multiplier® facilitates a high, predictable, reproducible throughput with minimized downtime and advanced safety features. The Gansons Pharmaceutical Integrated granulation line including High speed Mixer & Granulator, Inline Wet mill, Fluid Bed Dryer & Granulator, Lifting device with Inline Dry Mill, and IBC Lift Blender at different sizes depending on customer demand.
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Fluid Bed Top Spray Granulation
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Fluid Bed Equpment-Processor- Top Spray Granulation High Precision Fluidize Drying, Granulating, Agglomerating & Coating Process Technic Application & Process : Prism Fluid Bed Processing involves drying, cooling, agglomeration, granulation and coating of particulate materials. It is ideal for heat sensitive and non heat sensitive products in Pharmaceuticals, Biotech, Nutraceuticals, Cosmetic, Chemicals, Biochemical, Food, Dairy, Confectionery, Agrochemical, Herbals, Ceramics, Detergents and Pharma Institutes. Depending on the application required Prism fluid bed Equipment can be configured into designs as follows: 1. The Fluid Bed Mixing and Drying Process : The Fluid Bed system have a bed of solid particles which are fluidized by passing a stream of air upward through a specially designed perforated sheet. The upward velocity of air is so maintained so as to slightly lift the solid particles and set them in motion. This motion can be utilized to bring about mixing as well as forward movement of the solids particles. The air is heated and the process hot air evaporates the fluid and dries the solids. Fines get agglomerated to larger granules particles thus providing large size 2. The Fluid Bed Processor with Top spraying system for Agglomeration and Granulation Process :The process is used in fluid beds to form granules form a fine powder. The fluidized powder is wetted with fluid / binder / starch pest by using top spraying system. The top spraying system provided with spraying nozzle and precise dosing peristaltic pump. The fluidized powder is wetted until liquid bridges are formed between particles. Segregation of powder doesn't take place as different powder is glued together on a micro scale. Since there is no impinging force in fluid bed equipments the granules are weak and having good solubility. Once the granules are made they are dried in the equipment using hot air. This technology used for formed granules for Tabletting, capsule, dust free process, free flow properties, good dispensability and excellent solubility due to porous structure. Salient Features : Design is cGMP - Current Good Manufacturing Practices compliance. All contact parts AISI 316 & non contact parts AISI 304. High Mixing Precision, Short Batch Time, Problem free Cleaning and Residue Free Discharge. Single piece construction & Integrated retarding chamber cum filter bag housing Top Spraying system for Granulation. Different Batch size capacity model available. Granulation system with advance PLC controls system with MMI Touch screen. Spraying system with atomized spraying gun and high precise flow peristaltic pump. Sampling pot on product container. Pneumatic Sealing of Filter Bag and Product container by inflatable silicon rubber tube. Inlet Air handler with Air Filter- Micro and HEPA and Heat Exchanger. Dual speed mixing impeller for mixing and intensify chopper for granulating. Optional Features : Combo model with Granulator and Pellets Coater. Flame Proof Electrical. Safety Features : Explosion flap ensures that there no damage to the person operating the machine if there is an explosion inside caused by mixture of air and dust. Blower stops if the air pressure in filter bag locking gasket drops below the set value.
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