Eye Treatment in Sector 38, Gurugram (1 service providers available)

Malignant melanoma of the conjunctiva presents as a raised, pigmented or nonpigmented lesion that appears in adult life. This lesion is uncommon but potentially lethal. It can arise in previously unblemished and unpigmented regions (approximately 10% of cases), from a preexisting nevus (approximately 20% of cases), or from the flat spreading pigmentation of primary acquired melanosis with atypia (60-70% of cases). Pathophysiology Primary site: Together with mucus-secreting goblet cells within the stratified epithelium, melanocytic cells exist in the basal layer of the conjunctiva. These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. Melanomas may arise from junctional and compound nevi. Some uncertainty exists regarding the role of nevi in the histogenesis of malignant melanoma. Previously, compressed cells at the melanoma base have been considered to be nevi, but recent reports suggest that these flattened cells are, in fact, compressed melanoma cells and not nevus cells. Melanomas also may arise from primary acquired melanosis or de novo. Regional lymph nodes: The regional lymph nodes are parotid, preauricular, submandibular, and cervical. For pN (see Staging), histologic examination of a regional lymphadenectomy specimen ordinarily includes 6 or more regional lymph nodes. Metastatic sites: In addition to spread by lymphatics and the bloodstream, direct extension to the eyeball and orbit occurs.