Pharmtak Ophthalmics (I) Pvt. Ltd. Borivali East, Mumbai, Maharashtra

TOBRAMYCIN IS WIDELY ADMINISTERED AMINO GLYCOSIDE ANTIBIOTIC FOR OCULAR INFECTIONS BECAUSE OF ITS EFFICIENCY TO ELIMINATE GRAM-NEGATIVE BACTERIA ESPECIALLY PSEUDOMONAS SPECIES. IT IS PREFERRED DUE TO ITS BROAD SPECTRUM THAT COVERS STRAINS RESISTANT TO GENTAMYCIN. TOBRAMYCIN READILY BINDS WITH THE RIBOSOMAL PAIR DISABLING IT TO PRODUCE M-RNA RESPONSIBLE FOR THE PROTEIN FORMATION IN BACTERIA THUS ENSURING CELL DEATH. IT ALSO DESTABILIZES THE BACTERIAL MEMBRANE BY BINDING THE 16S R-RNA THUS THE FUNCTIONAL INTEGRITY OF THE BACTERIAL CELL MEMBRANE APPEARS TO BE DISRUPTED.

Ophthalmic drops of Cephalosporin works against a wide range of gram positive and negative bacteria. Cefatak not only works as an antibiotic but also helps other antibiotic drugs against the action of β lactamases produced by the bacteria in response to these antibiotics. It treats infections caused by bacterial strains producing enzymes like penicillinase, β lactamase, etc that have an ability to resist β lactam antibiotics.