Seema Biotech Bhandup East, Mumbai, Maharashtra

Appearane : Fine Whitishpowder  Solution Complies  Heavy Metals :

CAS No. : 3380-34-5

Country of Origin : India

Other Names : 5-chloro-

Color : whitish powder

SR. NO TESTS SPECIFICATION 1. Description A White Crystalline Powder. 2. Solubility Freely Soluble in Water, Very Soluble in Boiling Water, Insoluble in Alcohol 3. Identification As Per USP 28, Test ‘A’ & ‘B’. 4. Alkalinity As Per USP 28 5. Water NMT 1.0% 6. Tartrate As Per USP 28 7. Heavy Metals As Per USP 28 8. Assay On Anhydrous Basis 99.0% To 100.5

Brand Name : seema biotech

Country of Origin : India

Melting point >300 °C (lit.) Boiling point 281.88°C (rough estimate) Density 1.0806 (rough estimate) vapor pressure 1.72hPa at 25℃ refractive index 1.4186 (estimate) storage temp. 2-8°C solubility Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent). form Crystalline Powder pka pKa 4.3 (Uncertain);10.6 (Uncertain) color White Water Solubility 1g/6ml

Form : Powder,Crystalline Powder

Packaging Type : bag

Type : Tranexamic Acid

Country of Origin : India

SR. NO TEST SPECIFICATION 1. Description Pale yellow liquid, turning brownish on Standing. 2. Moisture Contents (by KF) Max. 0.50 % w/w 3. Solubility Miscible with organic solvents 4. Density [at ambient] 1.200 – 1.237 gm/ml 5. Purity [by GC] Min. 99.00 % Area 6. Related Substances A. Thiophene-3-Aldehyde Max. 0.10 % Area B. Total impurities Max. 1.00 % Area

Application : Pale yellow liquid, turning brownish on Standing.

CAS No. : 98-03-2

Purity : 99%

Appearance : Pale yellow liquid, turning brownish on Standing.

Country of Origin : India

Formula : C5H4OS

Tetramisole is an alkaline phosphatase inhibitor. It is a racemic mixture of (+) and (-) isomers. The (-) isomer (levamisole) accounts for most of the biological activity of tetramisole. Tetramisole is an anthelminthic agent used in veterinary applications to treat helminth or worm infections. Appearance: White powder Molecular formula: C11H12N2S×HCl Molecular weight: 240.8 Dissociation Constant: pKa = 8.01 Melting point: 264-265°C 2 

Color : WHITE

Appearance : powder to crystal

Form : powder

Packaging Type : drum

Melting point -45 °C (lit.) Boiling point 88 °C (lit.) Density 0.881 g/mL at 25 °C (lit.) vapor density 3 (vs air) refractive index n20/D 1.42(lit.) Flash point 4 °F storage temp. Store below +30°C. solubility >80.2g/l form Liquid color Clear colorless Odor at 0.10?%?in?dipropylene glycol. pungent sweet ethereal Water Solubility 80 g/L (25 ºC)

Melting Point : -45 °C (lit.)

Boiling Point : 88 °C (lit.)

Density : 0.881 g/mL at 25 °C (lit.)

Refractive Index : n20/D 1.42(lit.)

Appearance : Pale straw to colorless liquid

TESTS REQUIREMENTS RESULT Description A clear and colorless to slightly yellow syrupy liquid Clear amber syrupy liquid Identification A)    Yellow precipitate is produced B)     Yellow colour produced slowly in chloroform layer C)     The precipitate dissolved with difficulty A)    Complies B)     Complies C)     Complies Acidity or alkalinity NMT 1.0 ml of either 0.1M HCl or 0.1N NaOH 4 ml Relative Density 0.9000-1.00 0.984 Miscibility with ethanol  Mix a volume of the solution containing 1.6g of Cetrimide with a mixture of 2ml of water and 16ml of ethanol (96%). The solution remains clear. Complies Neutral Substance NMT 0.4g Complies Non-quaternized amines The odour of pyridine is not immediately perceptible. Complies Assay on anhydrous basis 98.5% to 102% 99.74%

SR.NO TEST SPECIFICATION RESULTS 1. Appearance White to creamy- White, Crystalline powder, free flowing, Odorless to having a slight odour. Is stable in air, but turns yellow on exposure to light. Complies 2. Solubility Free soluble in 30% ammonium solution: slightly soluble in acetone; Practically insoluble in alcohol, in chloroform and in ether. Decomposes in moderately strong mineral acids. Complies 3. Identification: a.      Infrared Absorption b.      HPLC     c. Test for silver A. IR test should be concordant with IR of standard. B. The retention time of the major peak of the sample solution corresponds to the standard solution, as obtained in the assay. C. Meets the requirements. Complies 4. Loss on drying 0.50 % Max 0.24% 5. Assay on dried basis NLT 98% and NMT 102.0%calculated on dried basis 100.52% 6. Nitrate NMT 0.1 % Max. 0.044% 7. Silver Content NLT- 29.3 % and NMT 30.5% silver found 29.78% 8. Organic Impurities a.      Sulfanilic acid b.      Sulphaguanidine c.       Sulfanilamide d.      2-Aminopyrilidine e.      Sulfadiazine f.       Acetyl Sulphadiazine g.      Specified unidentified Impurity h.      Individual unidentified Impurity i.        Total Impurity   A)     Not more than 0.3% B)      Should be Absent C)      Should be Absent D)     Not more than 0.3% E)      Should be Absent F)      Not More than 0.2% G)     Not More than 0.15% H)     Not More than 0.10% I)       Not More than 0.5%       a.      Not Detected b.      Not Detected c.       Not Detected d.      Not Detected e.      Not Detected f.       Not Detected g.      Not Detected h.      Not Detected i.        Not Detected     Physical Properties 1. Particle Size     A. Average Particle Size NMT 10 µm 100 %40 µm

Brand Name : seema biotech

Country of Origin : India

SR NO TEST SPECIFICATION RESULT 1. Description White or almost white slightly hygroscopic crystalline powder. White Powder. 2. Solubility Slightly soluble in water and in methanol Practically insoluble in hexane. Complies 3. Identification By IR The IR absorption spectrum of sample should match to the spectrum of sildenafil citrate working standard. Complies 4. Limit of Imidazole by TLC (%) Not more than 0.1 Complies 5. Organic Impurity by HPLC (%) Impurity-A                               Not more than 0.3 Any other Unspecified Individual Impurity              Not more than 0.10 Total unspecified Impurities                                Not more than 0.3 Total Impurities                      Not more than 0.5 Not Detected   0.05   0.05 0.05 6. Water content by KF (% w/w) Not more than 2.5 1.60 7. Residue on Ignition Not more than 0.1 0.06

Application : White or almost white slightly hygroscopic crystalline powder.

Brand Name : seema biotech

Form : powder

Purity : 99%

Packaging Size : 25 kg

Country of Origin : India

TESTS SPECIFICATION RESULT Description White off white crystal usually in fine needless or fluffy white crystalline powder A white crystalline powder Solubility Freely soluble in alcohol Complies Identification It responds to the test forbv salicylates Complies Melting range Between 158-161°C 158.1-160.8°C Loss of drying NMT0.5% w/w 0.30% Assay (By Titrometry) NLT-99.0%w/w 99.75%

Brand Name : seema biotech

CAS No. : 69-72-7

Purity : 99%

Country of Origin : India

Melting point -63 °C Boiling point 87-88 °C/760 mmHg (lit.) Density 0.852 g/mL at 25 °C (lit.) vapor density 2.45 (vs air) vapor pressure 128 mm Hg ( 39 °C) refractive index n20/D 1.443(lit.) Flash point 37 °F storage temp. Store below +30°C. solubility water: miscible form Liquid pka 11.27(at 25℃) color Colorless to Almost colorless Odor at 0.10 % in propylene glycol. ammoniacal animal egg amine PH 12.9 (100g/l, H2O, 20℃) explosive limit 1.6-10.6%(V) Odor Type ammoniacal Water Solubility Miscible with alcohol, ether, chloroform and water.

Color : Colorless to Almost colorless

Solubility : water: miscible

Boiling Point : 87-88 °C/760 mmHg (lit.)

Density : 0.852 g/mL at 25 °C (lit.)

Sr. No. Test Specification Result 1  Description  White Crystals  Complies 2  Assay(As kcl) (Titrimetry) (On dry basis)  98.0%  98.0% 3  Moisture  1.5%  1.2% 4  Sodium Chloride Flame Photometry  1%  0.6% 5  K2O content  60%  60.5%  

Brand Name : seema biotech

Color : White,White

Form : Powder,random crystals

Application : random crystals

CAS No. : 7447-40-7

Purity : 99%

Packaging Type : bag

Packaging Size : 25 Kg

Country of Origin : Made In India

Melting point −30 °C(lit.) Boiling point 169-170 °C(lit.) Density 0.966 g/mL at 25 °C(lit.) vapor pressure 2.266hPa at 25℃ refractive index n20/D 1.507(lit.) Flash point 135 °F storage temp. Sealed in dry,Room Temperature solubility alcohol: freely soluble(lit.) form Liquid pka 0[at 20 ℃] color Clear colorless to very slightly yellow Relative polarity 2.9 Water Solubility PRACTICALLY INSOLUBLE

Melting Point : −30 °C(lit.)

Boiling Point : 169-170 °C(lit.)

Refractive Index : n20/D 1.507(lit.)

Solubility : alcohol: freely soluble(lit.)

Form : liquid

Color : Clear colorless to very slightly yellow

Melting point >350°C Boiling point 220°C (rough estimate) Density 1.3588 (rough estimate) refractive index 1.6500 (estimate) pka pK1: 5.03 (25°C) form powder to crystal color Light yellow to Brown Water Solubility 0.2g/L(21 ºC)

Country of Origin : India

Boiling Point : 220°C (rough estimate)

Form : powder to crystal

Color : Light yellow to Brown

Appearance Clear, colourless liquid Purity (by GC) 99.5% minimum p-Cresol (by GC) 0.015% maximum Moisture (by KF) 0.15% maximum Colour (APHA) 50 maximum Odour Sweet, floral, cedar wood and camphor  

Application : Clear, colourless liquid

Purity : 99%

Packaging Type : drum

Packaging Size : 25 LITRE

Country of Origin : India

Appearance : Clear, colourless liquid

Purity : 99.5% minimum

Melting point 238-241 °C(lit.) Boiling point 274-276 °C Density 1.540 refractive index 1.5812 (estimate) Flash point 238 °C storage temp. room temp solubility methanol: soluble1%, clear, colorless to faintly yellow form Crystalline Powder pka 3.98(at 25℃) color White to yellow PH 4.3 (0.08g/l, H2O, 20℃) Water Solubility soluble in hot water

Color : white o yellow

CAS No. : 744-11-3

Purity : 97-99%

MF : C7H5ClO2

Country of Origin : India

Form : Crystalline Powder

Melting Point : 238-241 °C(lit.)

Boiling Point : 274-276 °C

TEST STANDARD OBSERVATIONS Appearance Almost White to White Crystalline powder Almost White to White Crystalline powder Solubility Insoluble in water, soluble in alkali hydroxide solution Confirms Melting Range 275°C - 280°C 277°C - 280°C Water Content (by KF) NMT 0.5% 0.22% Purity by HPLC p-Carboxy Benzene Sulfonamid NLT 99% 99.65% p-Toluene Sulfonamide NMT 0.5% 0.22% Any Unknown Impurity NMT 0.5% 0.13% Total Impurity NMT 1.0% 0.35%  

Country of Origin : India

SR.NO TEST SPECIFICATION RESULT 1. Description Colorless to Light yellow liquid Colorless 2. Boiling range 233°C to 234°C 233.8°C 3. Density (At 25°C) 1.05 to 1.10 g/ml 1.06 g/ml 4. Water content (By Kf) Not more than 0.5% w/w 0.04% 5. Purity & related Substance by GC Chromatographic Purity Not less than 99.00% 99.46% Benzyl alcohol Not more than 0.50% 0.10% Benzyl Chloride Not more than 0.50% 0.04% Single maximum impurity Not more than 0.50% 0.10% Total impurity Not more than 1.00% 0.14%  

Color : White to light yellow,White to light yellow

CAS No. : 150-13-0

MF : C7H7NO2

Appearance : Crystalline Powder

Physical State : Powder

Country of Origin : India

Melting point 157-159 °C Boiling point 266.91°C (rough estimate) Density 1.3245 (rough estimate) refractive index 1.5250 (estimate) storage temp. Sealed in dry,Room Temperature solubility 957mg/l form crystalline pka pK1: 3.10 (25°C) color White to light beige Water Solubility 848mg/L(25 ºC)

Brand Name : seema biotech

Color : White to light beige

Form : Crystals

CAS No. : 122-88-3

Purity : 99.9%

Packaging Type : Can

Appearance : crystalline

Country of Origin : India

TEST STANDARD OBSERVATIONS Appearance Almost White to White Crystalline powder Almost White to White Crystalline powder Solubility Insoluble in water, soluble in alkali hydroxide solution Confirms Melting Range 275°C - 280°C 277°C - 280°C Water Content (by KF) NMT 0.5% 0.22% Purity by HPLC p-Carboxy Benzene Sulfonamid NLT 99% 99.65% p-Toluene Sulfonamide NMT 0.5% 0.22% Any Unknown Impurity NMT 0.5% 0.13% Total Impurity NMT 1.0% 0.35%

CAS No. : 873-32-5

Purity : 99%

Country of Origin : India

Color : White to very slightly yellow

Not more than 0.50 % 0.22 % 6 % Purity by GC Any other single impurity Total Impurities Not less than 98.00% Not more than 1.00% Not more than 2.00% 99.59% 0.12% 0.41%

Melting Point : 53ᵒC To 58 ᵒC

Solubility : Soluble In Acetone And Methanol

Colour : Pale Yellow To Brown

Purity : Not less than 98.00%

ITEMS UNITS SYMBOLS STANDARD VALUES RESULTS P -PHENYLENE DIAMINE MG/KG ≤ 300 ND M -PHENYLENE DIAMINE MG/KG ≤ 300 ND APPEARANCE - = White flake WHITE FLAKE INITIAL MELTING POINT ᵒC ≥ 101.0 102.2 O - PHENYLENE DIAMINE % ≥ 99.9 99.98 O -CHLOROANILINE MG/KG ≤ 300 ND O - NITROANILINE MG/KG ≤ 100 ND PACKAGING BAG     400.00 NET WT.(UNIT) KGS     40.00 NET WT. (TOTAL) KGS     16,000.00 GROSS WT (TOTAL) KGS     16,160.00

Country of Origin : India

Packaging Type : Bag

Melting point 145-147 °C (lit.) Boiling point 240°C (estimate) Density 1.2143 (rough estimate) refractive index 1.4945 (estimate) storage temp. Sealed in dry,Room Temperature solubility Methanol, Water pka 4.17±0.10(Predicted) form Crystalline Powder color Light pink to light brown Water Solubility Soluble in Methanol and Water.

Color : Light pink to light brown,Light pink to light brown

Form : powder

Purity : 99.9%

Packaging Type : bag

Appearance : Light pink to light brown

Country of Origin : India

SR NO TEST RESULT SPECIFICATION   1   Physical Appearance   Off White Powder   White to off white powder   2   Clarity of 10% solution   Clear Solution   Solution should be clear   3   Moisture Content   10.29%   12.00% Max   4   Chlorides   Passes   05.00% Max   5   Purity (By Oxime Method )   88.4%   85.00%Min   6   Water Insoluble   Passes   00.02% Max   7   PH of 1% Solution   9.27   7.5 to 10

Form : powder

Chemical Formula : C7H5NaO4S

Usage/Application : Uses 2-Formylbenzenesulfonic acid sodium salt was used as precursor to test the ability of fungal st

Country of Origin : India