UMA Brothers Mumbai, Maharashtra

Zinc sulfate monohydrate can be used in electrolytes for zinc plating. It can be used as a mordant in dyeing. It can also be used in medicine as an astringent and emetic. Zinc sulfate monohydrate can be used to supply zinc in animal feeds, fertilizers, and agricultural sprays.

Voglibose is a valiolamine derivative & inhibitor of alpha-glucosidase with antihyperglycemic activity. Voglibose binds to & inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides & disaccharides into- glucose & other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose & decreases the rise in post- prandial blood glucose levels. Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose is orally active maltase-glucoamylase (α-glucosidase) inhibitor (ic50 values are 3.9 & 6.4 nm at sucrase & maltase respectively). It increases glucagon-like peptide 1 (glp-1) secretion and also decreases food consumption in obob mice. Voglibose reduces plasma concentration of glucose, triglycerides and insulin in wistar fatty rats additionally, voglibose exhibits antidiabetic and antiobesity activity in vivo.

Type : COLOURLESS CRYSTALLINE SOLID POWDER

Vincristine is an antitumor alkaloid isolated from vinca rosea. vincristine is an antitumor vinca alkaloid isolated from vinca rosea. It is marketed under several brand names, many of which have different formulations such as marqibo (liposomal injection) and vincasar. vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, hodgkin's disease, acute erythraemia, and acute panmyelosis. Vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone-marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).

Vecuronium bromide is the bromide salt form of vecuronium, a synthetic steroid derivative of the naturally occurring alkaloids of curare with a muscle relaxant property. Vecuronium bromide competes with acetyl- choline for the nicotinic receptors at the neuromuscular junction of skeletal muscles, thereby inhibiting the action of acetylcholine and blocking the neural transmission without depolarizing the postsynaptic membrane. This leads to skeletal muscle relaxation and paralysis. Monoquaternary homolog of pancuronium a non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.

Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (nsaid) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (cox)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This nsaid does not inhibit cox-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.

Valacyclovir is a herpes simplex virus nucleoside analog dna polymerase inhibitor, herpes zoster virus nucleoside analog dna polymerase inhibitor & herpesvirus nucleoside analog dna polymerase inhibitor. The mechanism of action of valacyclovir is as a dna polymerase inhibitor. The chemical classification of valacyclovir is nucleoside analog. Valacyclovir is the hydrochloride salt of the l-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral dna replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes.acyclovir triphosphate competitively inhibits viral dna polymerase; incorporates into and terminates the growing viral dna chain; and inactivates viral dna polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (hsv) compared with varicella-zoster virus (vzv) is due to its more efficient phosphorylation by hsv thymidine kinase.

Tropicamide is a machr m4 antagonist (id50=214.20 nmoles) found on blood vessels and neuronal cells. The compound can weaken anti-inflammatory effects and is used in ocular studies. One of the muscarinic antagonists with pharmacologic action similar to atropine and used mainly as an ophthalmic parasympatholytic or mydriatic.

Triprolidine hydrochloride is a component of cough and cold medicines. It may cause drowsiness. Histamine h1 antagonist used in allergic rhinitis; asthma; and urticaria.

Torasemide is a loop diuretic. The physiologic effect of torsemide is by means of increased diuresis at loop of henle. Torasemide is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.

Topiramate is a sulfamate-substituted monosaccharide with anti- convulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizeskainateampa subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing & decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (gaba) activity & thereby attenuating gabanergic inhibitory transmission.

Type : Pure

Purity : 100%

Tolnaftate is a synthetic antifungal agent. Tolnaftate is a thiocar- bamate derivative with either fungicidal or fungistatic property. tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2, 3- epoxidase, and an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.

Tizanidine hydrochloride is the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine & increasing the inhibitory effect on alpha motor neurons & motor reflexes. tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors & imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall tizanidine hydrochloride causes muscle relaxation reduces spasticity & antinociceptive effects.

Type : OFF-WHITE TO PALE YELLOW SOLID

CAS No. : 64461-82-1

Tinidazole is a nitroimidazole antitrichomonal agent effective against trichomonas vaginalis, entamoeba histolytica, and giardia lamblia infections. Tinidazole is a nitroimidazole antimicrobial. The chemical classification of tinidazole is nitroimidazoles. Tinidazole is a 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized & yields nitrite anions & metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and dna strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

Type : WHITE CRYSTALLINE SOLID POWDER

Brand Name : WHITE CRYSTALLINE SOLID POWDER

CAS No. : 19387-91-8

Timolol anhydrous is a beta-adrenergic blocker. The mechanism of action of timolol anhydrous is as an adrenergic beta-antagonist. A beta-adrenergic antagonist similar in action to propranolol.the levo-isomer is the more active. Timolol has been proposed as an antihyper- tensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor.

Thiocolchicoside is a small molecule muscle relaxant and anti-inflammatory agent, shown to function as a competitive gabaa (gamma-aminobutyric acid type a) receptor antagonist. Thiocolchicoside is also shown to inhibit strychnine-sensitive glyr (glycine receptors)with lower potency than gabaa, and to inhibit human achr (nicotinic acetylcholine receptors) with very low relative affinity.

Terlipressin acetate is an analogue of vasopressin used as a vasoactive for proteomics research. It has been found to be effective when norepinephrine is not.

Terbutaline is a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. Terbutaline is a î�-adrenoceptor agonist. Terbutaline is an activator of î�2-ar.

Tenofovir is an adenine analog reverse transcriptase inhibitor with antiviral activity against hiv-1 and hepatitis b. It is used to treat hiv infections and chronic hepatitis b, in combination with other antiviral agents, due to the emergence of antiviral drug resistance when it is used alone. Tenofovir anhydrous is a human immunodeficiency virus nucleoside analog reverse transcriptase inhibitor and hepatitis b virus nucleoside analog reverse transcriptase inhibitor. The mechanism of action of tenofovir anhydrous is as a nucleoside reverse transcriptase inhibitor. The chemical classification of tenofovir anhydrous is nucleoside analog.

Tazarotene is a retinoid. The chemical classification of tazarotene is retinoids. Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (tig3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.

It Is Sulfonamide Derivative With Adrenergic Antagonist Activity. Tamsulosin Selectivity Binds To And Blocks The Activity Of Alpha1 Adrenoreceptors In The Human Prostate, Prostatic Capsule, Prostatic Urethra & Bladder Neck. Blockade Of These   Adrenoceptors Can Cause Smooth Muscle In The Prostate And Bladder Neck To Relax, Resulting In An Improvement In Urinary Flow Rate. At Least Three Discrete Alpha1-adrenoceptor Subtypes Have Been Identified - Alpha-1a, Alpha-1b And Alpha-1d; Their Distribution Differs Between Human Organs And Tissue. Approximately 70% Of The Alpha1-receptors In Human Prostate Are Of The Alpha-1a Subtype. Tamsulosin Is A Α1 Aadrenergic Receptor Antagonist Used In The Symptomatic Treatment Of Benign Prostatic Hyperplasia (Bph). Tamsulosin Is Used To Improve Urination In Men With Benign Prostatic Hyperplasia (Enlarged Prostate).Details Synonyms - 5-(2-((2-(2-ethoxyphenoxy) Ethyl) Amino) Propyl)-2-methoxy Benzenesulfonamide, Hcl Cas Number - 106463-17-6 Mol. Formula - C20h29cln2o5s Mol.wght - 444.97. It Is White Crystalline Powder With Melting Range Of 226.1° To 227.8 °c & Slightly Soluble In Ethanol/water & Freely Soluble In Formic Acid. Standard - Offered Of Pharmaceutical Grade BP/USP/EP & Pellets Packing - Offered In Export Worthy Packing Of 1 Kilo Or As Per Our Customer Requirements.

Type : Pharmaceutical Raw Material

Form : Powder

Grade Standard : Pharmaceutical Grade BP/USP/EP & Pellets

Tamoxifen is an estrogen agonistantagonist. The mechanism of action of tamoxifen is as a selective estrogen receptor modulator one of the selective estrogen receptor modulators with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue but as an estrogen (stimulating agent) in cholesterol metabolism, bone density &cell proliferation in the endometrium.tamoxifen base is an antineoplastic nonsteroidal selective estrogen receptor modulator (serm). Tamoxifen competitively inhibits the binding of estradiol to estro- gen receptors, thereby preventing the receptor from binding to the estrogen-response element on dna. The result is a reduction in dna synthesis & cellular response to estrogen. In additiontamoxifen up-regulates the production of transforming growth factor b (tgfb), a factor that inhibits tumor cell growth & down-regulates insulin-like growth factor 1 a factor that stimulates breast cancer cell growth.

Tacrolimus is a macrolide isolated from the culture broth of a strain of streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus anhydrous is a calcineurin inhibitor immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a calcineurin inhibitor. Anhydrous from of tacrolimus, a macrolide isolated from streptomyces tsukubaensis. Tacrolimus binds to the fkbp-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo & prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.

Type : WHITE CRYSTALLINE SOLID POWDER

Color : WHITE CRYSTALLINE SOLID POWDER

CAS No. : 104987-11-3

Sumatriptan is a serotonin agonist that acts selectively at 5ht1 receptors. It is used in the treatment of migraine disorders. Sumatriptan is a serotonin-1b and serotonin-1d receptor agonist. The mechanism of action of sumatriptan is as a serotonin 1b receptor agonist & serotonin 1d receptor agonist. Sumatriptan is a sulfonamide triptan with vasoconstrictor activity. sumatriptan selectively binds to & activates serotonin 5-ht1d receptors in the central nervous system (cns), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.

Stavudine is a dideoxynucleoside analog that inhibits reverse transcrip- tase & has in vitro activity against hiv. Stavudine is a human immuno- deficiency virus nucleoside analog reverse transcriptase inhibitor. The mechanism of action of stavudine is as a nucleoside reverses transcrip- tase inhibitor. The chemical classification of stavudine is nucleoside analog. Stavudine is a nucleoside reverse transcriptase inhibitor analog of thymidine. Stavudine has been recommended to undergo phase-out management due to its long-term, irreversible side-effects.