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Tadalafil is a prescription medicine used to treat impotence, known medically as erectile dysfunction (ED), and symptoms of enlarged prostate (benign prostatic hyperplasia, or BPH). It is also is used to improve the ability to exercise in people with pulmonary arterial hypertension. Tadalafil is in a group of medications called phosphodiesterase 5 (PDE5) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. It may also relax the prostate and bladder. Tadalafil comes in tablet form and is either taken one time before you expect to have sexual activity, or at a lower dose, once daily.Common side effects include headache, indigestion, back pain, and facial flushing. Do not take tadalafil if you are taking other medications called "nitrates."