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Trazodone Hydrochloride used for the treatment of depression. However, it is sometimes prescribed as a sedative, and it also is used in combination with other drugs for the treatment of psychiatric conditions.  For the treatment of depression, the typical dose for adults is 150-600 mg per day. The initial dose usually is 150 mg per day. Trazodone is given in one or more divided doses, sometimes with the largest dose at night. Doses often are adjusted slowly upwards to find the optimal dose. Elderly patients and debilitated persons may need lower doses. Your physician will tell you your recommended dosage.