Homology Modelling Service
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The term “homology modeling“, also called comparative modeling or sometimes template-based modelling (TBM), refers to modeling a protein 3D structure using a known experimental structure of a homologous protein (the template). We at RASA follow a comparative modelling routine needing three items of input: The sequence of the protein with unknown 3D structure, the “target sequence“, a 3D template is chosen by virtue of having the highest sequence identity with the target sequence. Structural information is always of great assistance in the study of protein function, dynamics, interactions with ligands and other proteins. The “low-resolution” structure provided by homology modeling contains sufficient information about the spatial arrangement of important residues in the protein and may guide the design of new experiments, for example site-directed mutagenesis. Even within the pharmaceutical industry homology modeling can be valuable in structure-based drug discovery and drug design.
Financial Modeling - Training
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Financial Modeling - Training
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