G J Pharmaceuticals LLP Bhayandar, Thane, Maharashtra

Type : Injection

Dosage Form : Injection

Medicine Type : Allopathic

Packaging Size : 100ml

Packaging Type : Plastic Bottle

Type : Finished Product

Grade : Store In Cool And Dry Place

Storage : Store in cool and dry place

Type : Finished Product

Dosage Form : Injection

Grade : Medicine Grade

Feature : Perfect Composition

Feature : Perfect Composition

Why is this medication prescribed? Trastuzumab injection is used along with other medications or after other medications have been used to treat a certain type of breast cancer that has spread to other parts of the body. Trastuzumab injection is also used during and after treatment with other medications to decrease the chance that a certain type of breast cancer will return in women. Trastuzumab is also used with other medications to treat certain types of stomach cancer that have spread to other parts of the body. Trastuzumab is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.   How should this medicine be used? Trastuzumab injection comes as a liquid to be injected into a vein by a doctor or nurse in a hospital or medical facility. When trastuzumab injection is used to treat breast cancer that has spread, it is usually given once a week. When trastuzumab injection is used to prevent the return of breast cancer, it is usually given once a week during treatment with other chemotherapy medications, and then once every 3 weeks after treatment with the other medications is completed for up to 52 weeks. When trastuzumab injection is used to treat stomach cancer, it is usually given once every 3 weeks. The length of your treatment depends on how well your body responds to the medication and the side effects that you experience.   What special precautions should I follow? tell your doctor and pharmacist if you are allergic to trastuzumab, medications made from Chinese hamster ovary cell protein, any other medications, or benzyl alcohol. Ask your pharmacist if you are not sure if a medication you are allergic to is made from Chinese hamster ovary cell protein or contains benzyl alcohol. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and paclitaxel (Abraxane, Taxol). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or any other medical condition. tell your doctor if you are breast-feeding. if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving trastuzumab injection.   What side effects can this medication cause? diarrhea constipation stomach pain heartburn loss of appetite back, bone, joint, or muscle pain difficulty falling asleep or staying asleep hot flushes numbness, burning, or tingling in the arms, hands, feet, or legs changes in the appearance of nails acne depression   In case of emergency/overdose In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Brand Name : GJ

Description:Streptase, Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. It is supplied as a lyophilized white powder containing 25 mg cross-linked gelatin polypeptides, 25 mg sodium L-glutamate, sodium hydroxide to adjust pH, and 100 mg Albumin (Human) per vial or infusion bottle as stabilizers. The preparation contains no preservatives and is intended for intravenous and intracoronary administration. Indications:Acute Evolving Transmural Myocardial Infarction: Streptase, Streptokinase, is indicated for use in the management of acute myocardial infarction (AMI) in adults, for the lysis of intracoronary thrombi, the improvement of ventricular function, and the reduction of mortality associated with AMI, when administered by either the intravenous or the intracoronary route, as well as for the reduction of infarct size and congestive heart failure associated with AMI when administered by the intravenous route. Earlier administration of Streptokinase is correlated with greater clinical benefit. (See CLINICAL PHARMACOLOGY.) Pulmonary Embolism:   Streptase, Streptokinase, is indicated for the lysis of objectively diagnosed (angiography or lung scan) pulmonary emboli, involving obstruction of blood flow to a lobe or multiple segments, with or without unstable hemodynamics. Deep Vein Thrombosis:   Streptase, Streptokinase, is indicated for the lysis of objectively diagnosed (preferably ascending venography), acute, extensive thrombi of the deep veins such as those involving the popliteal and more proximal vessels. Arterial Thrombosis or Embolism:   Streptase, Streptokinase, is indicated for the lysis of acute arterial thrombi and emboli. Streptokinase is not indicated for arterial emboli originating from the left side of the heart due to the risk of new embolic phenomena such as cerebral embolism. Occlusion of Arteriovenous Cannulae:   Streptase, Streptokinase, is indicated as an alternative to surgical revision for clearing totally or partially occluded arteriovenous cannulae when acceptable flow cannot be achieved. Dosage and Administration : Acute Evolving Transmural Myocardial Infarction:   Administer Streptokinase as soon as possible after onset of symptoms. The greatest benefit in mortality reduction was observed when Streptokinase was administered within four hours, but statistically significant benefit has been reported up to 24 hours (see CLINICAL PHARMACOLOGY ). Warnings:Bleeding:   Following intravenous high-dose brief-duration Streptokinase therapy in acute myocardial infarction, severe bleeding complications requiring transfusion are extremely rare (0.3-0.5%), and combined therapy with low dose aspirin does not appear to increase the risk of major bleeding. The addition of aspirin to Streptokinase may cause a slight increase in the risk of minor bleeding (3.1% without aspirin vs. 3.9% with) (2) . Streptokinase will cause lysis of hemostatic fibrin deposits such as those occurring at sites of needle punctures, particularly when infused over several hours, and bleeding may occur from such sites. In order to minimize the risk of bleeding during treatment with Streptokinase, venipunctures and physical handling of the patient should be performed carefully and as infrequently as possible, and intramuscular injections must be avoided. Should an arterial puncture be necessary during intravenous therapy, upper extremity vessels are preferable. Pressure should be applied for at least 30 minutes, a pressure dressing applied, and the puncture site checked frequently for evidence of bleeding. In the following conditions the risks of therapy may be increased and should be weighed against the anticipated benefits. Recent (within 10 days) major surgery, obstetrical delivery, organ biopsy, previous puncture of noncompressible vessels Recent (within 10 days) serious gastrointestinal bleeding Recent (within 10 days) trauma including cardiopulmonary resuscitation Hypertension: systolic BP >180 mm Hg and/or diastolic BP >110 mm Hg High likelihood of left heart thrombus, e.g., mitral stenosis with atrial fibrillation Subacute bacterial endocarditis Hemostatic defects including those secondary to severe hepatic or renal disease Pregnancy Age >75 years Cerebrovascular disease

Brand Name : GJ

Packaging Size : Single vial

Packaging Size : 10 X 10 Tablets

Composition : Spiramycin 3 M.I.U.

Treatment : Helps To Prevent the Spread of The Infection To the Unborn Baby

Packaging Type : Box

Feature : Perfect Composition

Feature : Perfect Composition

Grade : Medicine Grade

Storage : Store in cool and dry place

Feature : Perfect Composition

Dosage : As per doctors prescription

Warnings: Contraindications Hypersensitivity History of (with prior L-asparaginase treatment): pancreatitis; hemorrhagic events; serious thrombosis Cautions: No more than 2 mL should be administered at any one injection site Anaphylaxis or serious allergic reactions may occur, monitor patient for 1 hr after administration; discontinue with serious allergic reactions Glucose intolerance reported (irreversible in some cases); monitor serum glucose Hepatotoxicity and abnormal liver function, including elevations of AST (SGOT), ALT (SGPT), alkaline phosphatase, bilirubin (direct and indirect), and depression of serum albumin, and plasma fibrinogen may occur; monitor Discontinue if pancreatitis occurs; evaluate patients with abdominal pain for pancreatitis Serious thrombotic events, including sagittal sinus thrombosis reported; discontinue if this occurs Increased prothrombin time, increased PTT and hypofibrinogenemia may occur; monitor for coagulopathy Pregnancy & Lactation Pregnancy Category: C Lactation: not known if excreted in breast milk Pregnancy Categories A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk. B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. Pharmacology Mechanism of Action Modified version of L-asparaginase depletes asparagine, the aminoacid required for protein synthesis, and in turn kills leukemic cells Pharmacokinetics Half-Life: 5-5.6 days Onset: Asparagine depleted within 4 days (IM) Duration: 21 days (IM); 2-4 weeks (IV in asparaginase naive adults) Vd: 1.5 L/m² (IM in children); 2.4 L/m² (IV in adults) Metabolism: Systemically Peak plasma time: 3-4 days (IM) Excretion: Urine (trace amounts) Storage Refrigerate Do not use if cloudy or if precipitate is present Do not freeze

Brand Name : GJ

Description : Paclitaxel Injection is a clear, colorless to slightly yellow viscous solution. It is supplied as anonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Paclitaxel is available in 30 mg (5 mL), 100 mg (16.7 mL), and 300 mg (50 mL) multidose vials. Each mL of sterile nonpyrogenic solution contains 6 mg paclitaxel, 527 mg of polyoxyl 35 castor oil, NF, 2 mg of anhydrous citric acid, USP and 49.7% (v/v) dehydrated alcohol, USP. Paclitaxel is a natural product with antitumor activity. Paclitaxel is obtained via a semi-synthetic process from Taxus baccata. The chemical name for paclitaxel is 5β, 20-Epoxy-1,2α,4,7β,10β,13α- hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3- phenylisoserine WARNING TAXOL® (paclitaxel) should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. Anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in 2 to 4% of patients receiving TAXOL in clinical trials. Fatal reactions have occurred in patients despite premedication. All patients should be pretreated with corticosteroids, diphenhydramine, and H2 antagonists.Patients who experience severe hypersensitivity reactions to TAXOL should not be rechallenged with the drug. Indications: Paclitaxel Injection is indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary. As first- line therapy, paclitaxel is indicated in combination with cisplatin. Paclitaxel Injection is indicated for the adjuvant treatment of node-positive breast cancer administered sequentially to standard doxorubicin-containing combination chemotherapy. In the clinical trial, there was an overall favorable effect on disease-free and overall survival in the total population of patients with receptor-positive and receptor-negative tumors, but the benefit has been specifically demonstrated by available data (median follow-up 30 months) only in the patients with estrogen and progesterone receptor negative tumors. Paclitaxel Injection is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.   Dosage and Administration Note: Contact of the undiluted concentrate with plasticized PVC equipment or devices used to prepare solutions for infusion is not recommended. In order to minimize patient exposure to the plasticizer DEHP [di-(2- ethylhexyl)phthalate], which may be leached from PVC infusion bags or sets, diluted paclitaxel injection solutions should be stored in bottles (glass, polypropylene) or plastic bags (polypropylene, polyolefin) and administered through polyethylene-lined administration sets. All patients should be premedicated prior to paclitaxel injection administration in order to prevent severe hypersensitivity reactions. Such premedication may consist of dexamethasone 20 mg PO administered approximately 12 and 6 hours before paclitaxel injection, diphenhydramine (or its equivalent) 50 mg IV 30 to 60 minutes prior to paclitaxel injection, and cimetidine (300 mg) or ranitidine (50 mg) IV 30 to 60 minutes before paclitaxel injection. Storage : Stored at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Protect from light. Retain in original carton.

Brand Name : GJ

Grade : Medicine Grade

Storage : Store in cool and dry place

Purity : 99%

Form : Capsules

Packaging Size : 10 Capsule per blister

Packaging Type : Box